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The reduction of anti-tumour diaziridinyl benzoquinones.

作者信息

Butler J, Hoey B M, Lea J S

出版信息

Biochim Biophys Acta. 1987 Aug 13;925(2):144-9. doi: 10.1016/0304-4165(87)90103-6.

DOI:10.1016/0304-4165(87)90103-6
PMID:3040109
Abstract

The properties of the semiquinone radicals produced for 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ), have been investigated. AZQ semiquinone radicals can be produced from the reduction of AZQ by superoxide radicals, whereas BZQ semiquinone radicals are unstable in the presence of oxygen. The one-electron reduction potentials of the couples Q/Q-. at pH 7.0 were determined as -70 +/- 10 mV for AZQ and -376 +/- 15 mV for BZQ. The difference in these potentials is explained. As a consequence of ESR studies on the enzymatically produced radicals, we have considered the factors which determine the detection of ESR signals for reduced quinones produced in a biological system.

摘要

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