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N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase.

作者信息

Focher F, Sangalli S, Ciarrocchi G, Della Valle G, Talarico D, Rebuzzini A, Wright G, Brown N, Spadari S

机构信息

Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia.

出版信息

Biochem Pharmacol. 1988 May 1;37(9):1877-8. doi: 10.1016/0006-2952(88)90491-1.

DOI:10.1016/0006-2952(88)90491-1
PMID:2837246
Abstract
摘要

相似文献

1
N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase.N2-取代鸟嘌呤衍生物作为单纯疱疹病毒I型胸苷激酶的选择性非底物抑制剂。
Biochem Pharmacol. 1988 May 1;37(9):1877-8. doi: 10.1016/0006-2952(88)90491-1.
2
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
J Med Chem. 1990 Jan;33(1):203-6. doi: 10.1021/jm00163a033.
3
Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.核苷类似物作为单纯疱疹病毒胸苷激酶的非底物抑制剂
Methods Find Exp Clin Pharmacol. 1989 Sep;11(9):577-82.
4
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.N2-苯基鸟嘌呤作为单纯疱疹病毒胸苷激酶抑制剂的定量构效关系
J Med Chem. 1992 Aug 7;35(16):2979-83. doi: 10.1021/jm00094a007.
5
N2-phenyldeoxyguanosine: a novel selective inhibitor of herpes simplex thymidine kinase.N2-苯基脱氧鸟苷：一种新型单纯疱疹胸苷激酶选择性抑制剂。
J Med Chem. 1988 Aug;31(8):1496-500. doi: 10.1021/jm00403a004.
6
QSAR and molecular graphics analysis of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
J Mol Graph Model. 2000 Feb;18(1):33-41. doi: 10.1016/s1093-3263(00)00032-2.
7
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.单纯疱疹病毒胸苷激酶的特异性抑制剂可减少潜伏病毒从移植的小鼠神经节中重新激活。
Antimicrob Agents Chemother. 1990 Jun;34(6):1285-6. doi: 10.1128/AAC.34.6.1285.
8
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.单纯疱疹病毒的胸苷激酶可使新型抗病毒化合物9-(2-羟乙氧甲基)鸟嘌呤发生磷酸化。
J Biol Chem. 1978 Dec 25;253(24):8721-7.
9
Efficiency of phosphorylation of the cyclobut-G (A-69992) enantiomers by HSV-1 thymidine kinase does not correlate with their anti-herpesvirus activity.单纯疱疹病毒1型胸苷激酶对环丁-G（A-69992）对映体的磷酸化效率与其抗疱疹病毒活性不相关。
Biochem Pharmacol. 1990 Dec 1;40(11):R5-10. doi: 10.1016/0006-2952(90)90076-w.
10
Modelling of guanine-derivative--protein interaction complexes as a basis of drug design.以鸟嘌呤衍生物 - 蛋白质相互作用复合物为基础进行药物设计的建模。
Farmaco. 1995 Jun;50(6):449-54.

引用本文的文献

1
Identification, partial purification and inhibition by guanine analogues of a novel enzymic activity which phosphorylates guanosine to GMP in the protozoan parasite Eimeria tenella.在原生动物寄生虫柔嫩艾美耳球虫中，一种将鸟苷磷酸化为GMP的新型酶活性的鉴定、部分纯化及鸟嘌呤类似物对其的抑制作用。
Biochem J. 1994 Mar 1;298 ( Pt 2)(Pt 2):289-94. doi: 10.1042/bj2980289.