单纯疱疹病毒胸苷激酶的特异性抑制剂可减少潜伏病毒从移植的小鼠神经节中重新激活。
Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
作者信息
Leib D A, Ruffner K L, Hildebrand C, Schaffer P A, Wright G E, Coen D M
机构信息
Laboratory of Tumor Virus Genetics, Dana Farber Cancer Institute, Boston, Massachusetts.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1285-6. doi: 10.1128/AAC.34.6.1285.
Abstract
Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.
摘要
对单纯疱疹病毒胸苷激酶的两种特异性抑制剂，即N2-苯基-2'-脱氧鸟苷和N2-(间三氟甲基苯基)鸟嘌呤，进行了测试，以考察它们抑制潜伏感染的小鼠三叉神经节外植体培养物中病毒再激活的能力。与未处理的对照相比，这两种化合物均显著降低了再激活频率。
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MUTANT STRAINS OF HERPES SIMPLEX DEFICIENT IN THYMIDINE KINASE-INDUCING ACTIVITY.胸苷激酶诱导活性缺陷的单纯疱疹突变株。
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Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.疱疹病毒对胸苷激酶和脱氧胞苷激酶活性的诱导作用。
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Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.病毒胸苷激酶抑制剂的证明及其对单纯疱疹病毒感染细胞中脱氧核苷酸代谢的影响。
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A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells.单纯疱疹病毒核糖核苷酸还原酶缺失突变体在小鼠的急性感染及潜伏感染再激活过程中存在缺陷，并且在小鼠细胞中无法复制。
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Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.脊髓神经节中由胸苷激酶缺陷型单纯疱疹病毒引起的潜伏感染
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Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.胸苷激酶阴性单纯疱疹病毒突变体可在小鼠三叉神经节中建立潜伏感染，但不会再激活。
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