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用辛德毕斯病毒或塞姆利基森林病毒预处理后,小鼠对感染兰加特(TP21)病毒的抵抗力增强。

Enhanced resistance of mice to infection with Langat (TP21) virus following pre-treatment with Sindbis or Semliki forest virus.

作者信息

Oaten S W, Webb H E, Bowen E T

出版信息

J Gen Virol. 1976 Dec;33(3):381-8. doi: 10.1099/0022-1317-33-3-381.

DOI:10.1099/0022-1317-33-3-381
PMID:187719
Abstract

Significant protection to heterologous i.c. challenge with the flavovirus Langat occurred after a single i.c. injection of avirulent strains of the alpha viruses Semliki Forest or Sindbis given 1 day to 5 weeks before challenge. Some protection also occurred after an i.p. infection with these viruses. We consider that the protection afforded by the alpha viruses is due to interference with the multiplication of Langat virus and is related to the maximum level of brain infectivity reached in the alpha virus infection.

摘要

在以黄病毒兰加特病毒进行异源脑内攻击前1天至5周,单次脑内注射α病毒塞姆利基森林病毒或辛德毕斯病毒的无毒株后,可对其产生显著保护作用。经这些病毒腹腔感染后也会产生一定程度的保护作用。我们认为,α病毒提供的保护作用是由于其干扰了兰加特病毒的增殖,并且与α病毒感染时脑内达到的最大感染水平有关。

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引用本文的文献

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Can viral envelope glycolipids produce auto-immunity, with reference to the CNS and multiple sclerosis?就中枢神经系统和多发性硬化而言,病毒包膜糖脂会引发自身免疫吗?
Neuropathol Appl Neurobiol. 1984 Jan-Feb;10(1):1-10. doi: 10.1111/j.1365-2990.1984.tb00335.x.
2
Semliki Forest virus induced, immune mediated demyelination: the effect of irradiation.塞姆利基森林病毒诱导的免疫介导性脱髓鞘:辐射的影响
Br J Exp Pathol. 1987 Feb;68(1):101-13.
3
CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus).
塞姆利基森林病毒(甲病毒属)和兰加特病毒(黄病毒属)双重病毒感染后的中枢神经系统发病机制。
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The relationship between axonal transport of protein and demyelination in the optic nerves of mice infected with Semliki Forest virus.感染Semliki森林病毒的小鼠视神经中蛋白质轴突运输与脱髓鞘之间的关系。
Brain Res. 1986 Nov 5;397(1):9-15. doi: 10.1016/0006-8993(86)91364-8.