Jayaraj A P
Department of Surgery, University College, London, UK.
Br J Exp Pathol. 1988 Apr;69(2):321-6.
The autotransplantation of liver into the subcutaneous tissues in rats and hamsters resulted in the development of periodic acid Schiffs staining positive granules, which were resistant to diastase digestion. These granules were confirmed as alpha-1-antitrypsin by immunohistochemical staining. The appearance of the alpha-1-antitrypsin containing hepatic granules is comparable to those seen in the liver of humans with genetically determined alpha-1-antitrypsin deficiency.
将肝脏自体移植到大鼠和仓鼠的皮下组织中，会导致过碘酸希夫染色阳性颗粒的形成，这些颗粒对淀粉酶消化具有抗性。通过免疫组织化学染色证实这些颗粒为α-1-抗胰蛋白酶。含有α-1-抗胰蛋白酶的肝脏颗粒的外观与在患有遗传性α-1-抗胰蛋白酶缺乏症的人类肝脏中所见的颗粒相当。
