Klatt E C, Koss M N, Young T S, Macauley L, Martin S E
Department of Pathology, Los Angeles County-University of Southern California Medical Center 90033.
Arch Pathol Lab Med. 1988 May;112(5):510-3.
We describe the presence of hyaline globules in liver associated with hepatic congestion. These globules were present in hepatocytes in 15% of 100 adult autopsies. They are periodic acid-Schiff (PAS)-positive and diastase-resistant by light microscopy, and in one case examined by electron microscopy, contained microfibrillar material with occasional rod-shaped inclusions. The majority of them stained positively for fibrinogen and alpha 1-antitrypsin by immunohistochemical methods. Of possible etiologies, the globules appear most probably as phagosomes containing imbibed serum proteins under conditions of increased sinusoidal pressure with passive congestion. They are more common than generally realized, when compared with other reported forms of nonglycogenic hyaline globules in liver. They must be distinguished from alpha 1-antitrypsin-disease globules.
我们描述了与肝淤血相关的肝脏中透明小球的存在情况。在100例成人尸检中，15%的肝细胞内存在这些小球。通过光学显微镜观察，它们对过碘酸希夫（PAS）染色呈阳性且耐淀粉酶消化，在1例经电子显微镜检查的病例中，发现其含有微纤维状物质及偶尔出现的杆状包涵体。通过免疫组织化学方法检测，其中大多数对纤维蛋白原和α1 -抗胰蛋白酶染色呈阳性。在可能的病因方面，这些小球很可能是在窦性压力升高伴被动性淤血的情况下，含有摄取血清蛋白的吞噬体。与肝脏中其他报道的非糖原性透明小球形式相比，它们更为常见。必须将它们与α1 -抗胰蛋白酶病小球区分开来。
