Davis J M, Bolton R E, Douglas A N, Jones A D, Smith T
Pathology Branch, Institute of Occupational Medicine, Edinburgh, UK.
Br J Ind Med. 1988 May;45(5):292-9. doi: 10.1136/oem.45.5.292.
Two groups of 48 rats of the AF/HAN strain were exposed for one year to respirable dust clouds of UICC chrysotile asbestos at a dose level of 10 mg/m3. One group was treated with dust carrying the normal electrostatic charge produced during dust generation, whereas the other was exposed to dust discharged by exposure to ionising radiation from a thallium-204 source. After dusting most animals were retained for their full life span. At the end of the dusting period those animals treated with normally charged dust had significantly more chrysotile retained in their lungs than animals exposed to discharged dust. Subsequently, animals treated with normally charged dust developed more pulmonary fibrosis and more pulmonary tumours. These findings suggest that the charge carried by airborne fibres should be taken into account when considering the health risks from exposure to chrysotile. Highly charged fibres are more likely to be deposited in lung tissue and thus constitute a greater hazard.
将两组各48只AF/HAN品系大鼠暴露于剂量为10毫克/立方米的国际癌症研究机构（UICC）温石棉可吸入粉尘云一年。一组用在粉尘产生过程中带有正常静电荷的粉尘进行处理，而另一组则暴露于通过铊-204源的电离辐射放电产生的粉尘中。撒粉后，大多数动物被保留至其整个寿命期。在撒粉期结束时，用带正常电荷粉尘处理的动物肺中保留的温石棉明显多于暴露于放电粉尘的动物。随后，用带正常电荷粉尘处理的动物出现了更多的肺纤维化和更多的肺肿瘤。这些发现表明，在考虑温石棉暴露的健康风险时，应考虑空气中纤维所带的电荷。高电荷纤维更有可能沉积在肺组织中，因此构成更大的危害。
