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2
IL-10 signaling prevents gluten-dependent intraepithelial CD4 cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine.IL-10 信号通路可防止小肠中 gluten 依赖的上皮内 CD4 细胞毒性 T 淋巴细胞浸润和上皮损伤。
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Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease.上皮应激和适应性免疫对上皮内杀伤细胞功能及活动性乳糜泻的独特协同作用。
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Intraepithelial lymphocytes in celiac disease immunopathology.腔上皮内淋巴细胞在乳糜泻免疫病理学中的作用。
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本文引用的文献

1
Diverse T Cell Receptor Gene Usage in HLA-DQ8-Associated Celiac Disease Converges into a Consensus Binding Solution.HLA-DQ8 相关乳糜泻中不同的 T 细胞受体基因使用趋于共识结合解决方案。
Structure. 2016 Oct 4;24(10):1643-1657. doi: 10.1016/j.str.2016.07.010. Epub 2016 Aug 25.
2
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes.乳糜泻肠道浆细胞的麸质特异性抗体识别通常含有T细胞表位的长蛋白水解片段。
Sci Rep. 2016 May 5;6:25565. doi: 10.1038/srep25565.
3
A biased view toward celiac disease.对乳糜泻的偏见观点。
Mucosal Immunol. 2016 May;9(3):583-6. doi: 10.1038/mi.2016.17. Epub 2016 Mar 23.
4
Understanding Celiac Disease by Genomics.从基因组学角度理解乳糜泻。
Trends Genet. 2016 May;32(5):295-308. doi: 10.1016/j.tig.2016.02.003. Epub 2016 Mar 10.
5
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease.健康的HLA-DQ2.5+受试者缺乏针对乳糜泻免疫显性麸质表位的调节性和记忆性T细胞。
J Immunol. 2016 Mar 15;196(6):2819-26. doi: 10.4049/jimmunol.1501152. Epub 2016 Feb 19.
6
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage.对与DQ2.5-神经胶质细胞-α2和DQ2.5-神经胶质细胞-ω2反应的单细胞进行TCR测序，揭示了克隆性扩增和表位特异性V基因使用情况。
Mucosal Immunol. 2016 May;9(3):587-96. doi: 10.1038/mi.2015.147. Epub 2016 Feb 3.
7
IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction.白细胞介素-15作为一种危险信号，可调节组织驻留T细胞和组织破坏。
Nat Rev Immunol. 2015 Dec;15(12):771-83. doi: 10.1038/nri3919. Epub 2015 Nov 16.
8
Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease.免疫球蛋白作为转谷氨酰胺酶2的底物：对乳糜泻自身抗体产生的影响
J Immunol. 2015 Dec 1;195(11):5159-68. doi: 10.4049/jimmunol.1501363. Epub 2015 Oct 26.
9
Cysteinyl leukotrienes mediate lymphokine killer activity induced by NKG2D and IL-15 in cytotoxic T cells during celiac disease.在乳糜泻期间，半胱氨酰白三烯介导细胞毒性T细胞中由NKG2D和IL-15诱导的淋巴因子杀伤活性。
J Exp Med. 2015 Sep 21;212(10):1487-95. doi: 10.1084/jem.20150303. Epub 2015 Aug 24.
10
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization.通过高效催化自多聚化增强B细胞受体对自身抗原转谷氨酰胺酶2的识别
PLoS One. 2015 Aug 5;10(8):e0134922. doi: 10.1371/journal.pone.0134922. eCollection 2015.

乳糜泻中的T细胞

T Cells in Celiac Disease.

作者信息

Jabri Bana, Sollid Ludvig M

机构信息

Department of Medicine, University of Chicago, Chicago, IL 60637;

Department of Pathology, University of Chicago, Chicago, IL 60637.

出版信息

J Immunol. 2017 Apr 15;198(8):3005-3014. doi: 10.4049/jimmunol.1601693.

DOI:10.4049/jimmunol.1601693
PMID:28373482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5426360/
Abstract

Celiac disease is a human T cell-mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.

摘要

乳糜泻是一种由遗传易感性个体摄入膳食麸质引发的人类T细胞介导的自身免疫样疾病。本综述将讨论针对外源性抗原的CD4 T细胞反应如何引发自身反应性B细胞反应，并参与上皮内淋巴细胞杀伤肠上皮细胞的许可过程。此外，本综述将探讨上皮内细胞毒性T细胞在乳糜泻中介导组织破坏的机制。