Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, Victoria, Australia.
Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Mucosal Immunol. 2016 May;9(3):583-6. doi: 10.1038/mi.2016.17. Epub 2016 Mar 23.
Celiac disease is an autoimmune-like disorder that is triggered by dietary gluten and has a strong genetic association with the human leukocyte antigen locus, specifically, HLA-DQ2.5/DQ8. Here, Dahai-Koirala et al. apply ex vivo single-cell sequencing of TCRs from celiac disease patients, and show that biased T-cell receptor usage underpins the response to two gluten epitopes, which has implications for disease pathogenesis, diagnosis, and treatment.
乳糜泻是一种自身免疫样疾病，由膳食麸质触发，与人白细胞抗原基因座有很强的遗传关联，特别是 HLA-DQ2.5/DQ8。在此，Dahai-Koirala 等人应用乳糜泻患者的 TCR 的体外单细胞测序，表明偏向性 T 细胞受体的使用为两种麸质表位的反应提供了基础，这对疾病的发病机制、诊断和治疗具有重要意义。
