Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom.
Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom
Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4195-4200. doi: 10.1073/pnas.1618934114. Epub 2017 Apr 3.
Animals adjust their behavioral priorities according to momentary needs and prior experience. We show that changes how it processes sensory information according to the oxygen environment it experienced recently. acclimated to 7% O are aroused by CO and repelled by pheromones that attract animals acclimated to 21% O This behavioral plasticity arises from prolonged activity differences in a circuit that continuously signals O levels. A sustained change in the activity of O-sensing neurons reprograms the properties of their postsynaptic partners, the RMG hub interneurons. RMG is gap-junctionally coupled to the ASK and ADL pheromone sensors that respectively drive pheromone attraction and repulsion. Prior O experience has opposite effects on the pheromone responsiveness of these neurons. These circuit changes provide a physiological correlate of altered pheromone valence. Our results suggest stores a memory of recent O experience in the RMG circuit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-dependent manner.
动物会根据当前的需求和以往的经验来调整行为优先级。我们发现，它会根据最近所处的氧气环境来改变其处理感官信息的方式。在 7%氧气环境中适应的 会被 CO 唤醒，而被吸引到 21%氧气环境中适应的 则会排斥信息素。这种行为可塑性源于一个连续信号氧气水平的电路中的长时间活动差异。氧气感应神经元活动的持续变化会重新编程它们的突触后伙伴——RMG 中枢神经元的特性。RMG 通过缝隙连接与 ASK 和 ADL 信息素传感器耦联，分别驱动信息素的吸引和排斥。先前的氧气经验对这些神经元的信息素反应有相反的影响。这些电路变化为改变信息素效价提供了生理相关性。我们的结果表明，在 RMG 电路中存储了最近氧气经验的记忆，并说明了电路如何以依赖上下文的方式灵活地塑造以指导行为决策。
