Faculty of Science and Engineering, Graduate School of Natural Science, Institute for Integrative Neurobiology, Konan University, Okamoto, Higashinada-ku, Kobe, Japan.
AMED-PRIME, Japan Agency for Medical Research and Development, Tokyo, Japan.
Adv Exp Med Biol. 2024;1461:33-46. doi: 10.1007/978-981-97-4584-5_3.
Organisms receive environmental information and respond accordingly in order to survive and proliferate. Temperature is the environmental factor of most immediate importance, as exceeding its life-supporting range renders essential biochemical reactions impossible. In this chapter, we introduce the mechanisms underlying cold tolerance and temperature acclimation in a model organism-the nematode Caenorhabditis elegans, at molecular and physiological levels. Recent investigations utilizing molecular genetics and neural calcium imaging have unveiled a novel perspective on cold tolerance within the nematode worm. Notably, the ASJ neuron, previously known to possess photosensitive properties, has been found to sense temperature and regulate the sperm and gut cell-mediated pathway underlying cold tolerance. We will also explore C. elegans' cold tolerance and cold acclimation at the molecular and tissue levels.
生物为了生存和繁殖，会接收环境信息并做出相应的反应。温度是最重要的环境因素，因为超出其维持生命的范围会使基本的生化反应无法进行。在本章中，我们将在分子和生理水平上介绍模式生物秀丽隐杆线虫的耐寒性和温度驯化的机制。最近利用分子遗传学和神经钙成像的研究揭示了线虫耐寒性的新视角。值得注意的是，先前已知具有感光特性的 ASJ 神经元能够感知温度，并调节精子和肠道细胞介导的耐寒性途径。我们还将探讨秀丽隐杆线虫在分子和组织水平上的耐寒性和冷驯化。
