Goyal Ahsas, Agrawal Neetu
Institute of Pharmaceutical Research, GLA University, Mathura 281406, U.P., India.
J Saudi Heart Assoc. 2017 Apr;29(2):116-127. doi: 10.1016/j.jsha.2016.09.002. Epub 2016 Sep 13.
Ischemic heart diseases are the leading cause of morbidity and mortality worldwide. Reperfusion of an ischemic heart is necessary to regain the normal functioning of the heart. However, abrupt reperfusion of an ischemic heart elicits a cascade of adverse events that leads to injury of the myocardium, i.e., ischemia-reperfusion injury. An endogenous powerful strategy to protect the ischemic heart is ischemic preconditioning, in which the myocardium is subjected to short periods of sublethal ischemia and reperfusion before the prolonged ischemic insult. However, it should be noted that the cardioprotective effect of preconditioning is attenuated in some pathological conditions. The aim of this article is to review present knowledge on how menopause and some metabolic disorders such as diabetes and hyperlipidemia affect myocardial ischemic preconditioning and the mechanisms involved.
缺血性心脏病是全球发病和死亡的主要原因。恢复缺血心脏的血液灌注对于恢复心脏的正常功能至关重要。然而，缺血心脏的突然再灌注会引发一系列不良事件，导致心肌损伤，即缺血-再灌注损伤。一种内源性的强大保护缺血心脏的策略是缺血预处理，即在长时间缺血损伤之前，使心肌经历短时间的亚致死性缺血和再灌注。然而，应该注意的是，在某些病理条件下，预处理的心脏保护作用会减弱。本文的目的是综述目前关于更年期以及糖尿病和高脂血症等一些代谢紊乱如何影响心肌缺血预处理及其相关机制的知识。
