Wang Pei, Luo Qingli, Tang Li
Department of Ophthalmology, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Wuhou District, Chengdu, 610041, Sichuan Province, China.
Int Ophthalmol. 2018 Apr;38(2):803-805. doi: 10.1007/s10792-017-0506-6. Epub 2017 Apr 3.
To report a rare case of extensive bilateral xanthelasma palpebrarum (XP). A 70-year-old man presented with nodular lesions of his eyelids for 12 years. The skin changes began with his left lower eyelid and progressively spread to both lateral-inferior and infero-medial periorbital areas. The lesions were yellow nodules that were hard, extensive, multiple and coalescent.
The tumors of this patient's eyelids underwent resection and tissue was processed for light microscopic examination.
Under light microscopy, many foamy xanthoma cells were found in the dermis, often nested around capillaries. Touton giant cell were also be observed, and tissue fibrous hyperplasia was obvious. The pathological changes were seen in the orbicularis oculi muscle, where many foamy xanthoma cells were seen between the muscle fibers.
XP is the most common cutaneous xanthoma and typically presents in the middle-aged and elderly. This presentation of XP is notable because of its extent. The light microscopic appearance confirmed the diagnosis of XP. Surgical intervention provided substantial cosmesis.
报告一例罕见的广泛性双侧睑黄瘤（XP）病例。一名70岁男性，眼睑出现结节性病变12年。皮肤改变始于左眼下睑，并逐渐蔓延至双侧眶外下和眶内下周边区域。病变为黄色结节，质地坚硬，范围广泛，多发且融合成片。
对该患者的眼睑肿瘤进行切除，并对组织进行光学显微镜检查。
在光学显微镜下，真皮层发现许多泡沫状黄色瘤细胞，常围绕毛细血管呈巢状分布。还观察到杜顿巨细胞，且组织纤维增生明显。眼轮匝肌也出现了病理改变，肌纤维间可见许多泡沫状黄色瘤细胞。
睑黄瘤是最常见的皮肤黄色瘤，通常见于中老年人。该例睑黄瘤的表现因其范围广泛而值得关注。光学显微镜下的表现确诊了睑黄瘤。手术干预显著改善了容貌。
