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染色质组装因子-1/p60的过表达可预测喉癌的生物学行为。

Overexpression of chromatin assembly factor-1/p60 predicts biological behaviour of laryngeal carcinomas.

作者信息

Mesolella M, Iorio B, Landi M, Cimmino M, Ilardi G, Iengo M, Mascolo M

机构信息

Department of Neurosciences, ENT Section, University of Naples "Federico II", Naples, A.O.U. Federico II, Naples, Italy.

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy.

出版信息

Acta Otorhinolaryngol Ital. 2017 Feb;37(1):17-24. doi: 10.14639/0392-100X-867.

DOI:10.14639/0392-100X-867
PMID:28374866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5384305/
Abstract

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

摘要

本研究分析了CAF-1/p60蛋白在喉癌中的免疫组化表达。CAF-1/p60在喉肿瘤中具有独立的鉴别和预后价值；与喉癌前病变和浸润性肿瘤相比，原位癌中该蛋白的存在情况。我们评估了30例中重度发育异常、30例原位癌和30例喉鳞状细胞癌（LSCC）中CAF-1/p60的免疫组化表达。根据肿瘤细胞高复制指数，CAF-1/p60表达显著增加；因此，CAF-1/p60在肿瘤细胞中过表达，与低表达相比，其中度至重度表达与较差的预后相关。总之，CAF-1/p60蛋白过表达与更高的发病率和死亡率风险相关，是喉癌可靠的独立预后指标。CAF1-p60蛋白过表达可作为恶性进展的指标用于癌症管理，尤其是在原位癌中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/4a607e7cc414/0392-100X-37-17-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/de093de88ae1/0392-100X-37-17-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/e4b51a53108c/0392-100X-37-17-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/10fd7f497737/0392-100X-37-17-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/4a607e7cc414/0392-100X-37-17-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/de093de88ae1/0392-100X-37-17-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/e4b51a53108c/0392-100X-37-17-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/10fd7f497737/0392-100X-37-17-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eee7/5384305/4a607e7cc414/0392-100X-37-17-g004.jpg

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