在一名家族性淀粉样多神经病患者的组织中，四种蛋白酶对淀粉样物质的体外降解作用。

In vitro degradation of amyloid material by four proteases in tissue of a patient with familial amyloidotic polyneuropathy.

作者信息

Adachi N, Koh C S, Tsukada N, Shoji S, Yanagisawa N

机构信息

Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

J Neurol Sci. 1988 Apr;84(2-3):295-9. doi: 10.1016/0022-510x(88)90133-5.

DOI:10.1016/0022-510x(88)90133-5

PMID:2837542

Abstract

The effects of 4 proteolytic enzymes, alpha-chymotrypsin, bromeline, collagenase, and lysozyme on amyloid tissue sections from a patient with familial amyloidotic polyneuropathy (FAP) were evaluated. Degradation of amyloid fibrils was significant with alpha-chymotrypsin, moderate with bromeline and collagenase, and slight with lysozyme. All of these proteases except collagenase are used as oral mucolytics in humans. The possibility of their clinical usefulness in the treatment or prevention of the development of FAP is discussed.

摘要

评估了4种蛋白水解酶，即α-糜蛋白酶、菠萝蛋白酶、胶原酶和溶菌酶对一名家族性淀粉样多神经病（FAP）患者的淀粉样组织切片的影响。α-糜蛋白酶对淀粉样纤维的降解作用显著，菠萝蛋白酶和胶原酶的作用中等，溶菌酶的作用轻微。除胶原酶外，所有这些蛋白酶在人类中都用作口服黏液溶解剂。讨论了它们在治疗或预防FAP发展方面临床应用的可能性。