Adachi N, Shoji S, Nakagawa S, Koh C S, Tsukada N, Yanagisawa N
Third Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
J Neurol Sci. 1987 Oct;81(1):79-84. doi: 10.1016/0022-510x(87)90185-7.
Serum levels of 6 protease inhibitors, alpha 1-antitrypsin, Cl inactivator, alpha 2-macroglobulin, antithrombin-3, alpha 1-antichymotrypsin and inter-alpha-trypsin inhibitor were measured in patients with familial amyloidotic polyneuropathy (FAP) and a control group without neurologic disease. No significant differences were observed between the 2 groups. The proteolytic effect of brinase, an enzyme from Aspergillus oryzae, on amyloid tissue sections from patients with FAP was also evaluated. Amyloid fibrils were degraded by brinase, while the tissue structure remained fairly intact.
在患有家族性淀粉样多神经病（FAP）的患者和无神经疾病的对照组中，检测了6种蛋白酶抑制剂的血清水平，即α1-抗胰蛋白酶、C1灭活剂、α2-巨球蛋白、抗凝血酶-3、α1-抗糜蛋白酶和α-胰蛋白酶抑制剂。两组之间未观察到显著差异。还评估了来源于米曲霉的一种酶——纤维蛋白酶对FAP患者淀粉样组织切片的蛋白水解作用。淀粉样纤维被纤维蛋白酶降解，而组织结构保持相当完整。
