Davis Laurie S, Reimold Andreas M
Rheumatic Diseases Division, Department of Internal Medicine, University of Texas Southwestern Medical Center.
Dallas VA Medical Center, Dallas, TX, USA.
Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i100-i113. doi: 10.1093/rheumatology/kew417.
This review summarizes traditional and emerging therapies for SLE. Evidence suggests that the heterogeneity of SLE is a crucial aspect contributing to the failure of large clinical trials for new targeted therapies. A clearer understanding of the mechanisms driving disease pathogenesis combined with recent advances in medical science are predicted to enable accelerated progress towards improved SLE diagnosis and personalized approaches to treatment.
本综述总结了系统性红斑狼疮（SLE）的传统疗法和新兴疗法。有证据表明，SLE的异质性是导致新靶向疗法大型临床试验失败的关键因素。预计更清楚地了解驱动疾病发病机制的因素，并结合医学科学的最新进展，将能加快SLE诊断的进展以及实现个性化治疗方法。
