Belani C P, Eisenberger M A, Gray W C
University of Maryland Cancer Center, Department of Medicine, Baltimore 21201.
Med Pediatr Oncol. 1988;16(3):197-202. doi: 10.1002/mpo.2950160309.
Eight patients with advanced incurable salivary gland carcinoma were treated with the combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). There were three clinical complete responses and two excellent partial responses. One of the three nonresponders had symptomatic improvement without any response in the measurable disease sites. Side effects were acceptable. All patients had moderate nausea and some degree of vomiting, which were adequately controlled by antiemetics. These results are preliminary but when considered with other reported trials using the same combination suggest an active treatment program for advanced neoplasms of the salivary glands.
8例晚期不可治愈性涎腺癌患者接受了环磷酰胺、阿霉素和顺铂联合治疗（CAP方案）。有3例获得临床完全缓解，2例获得显著部分缓解。3例无反应者中有1例出现症状改善，但可测量病灶部位无反应。副作用可以接受。所有患者均有中度恶心和一定程度的呕吐，通过使用止吐药可得到充分控制。这些结果是初步的，但与其他使用相同联合方案的报道试验相结合，提示该方案对晚期涎腺肿瘤是一种有效的治疗方案。
