Zhang Yongrui, Li Shuxin, Zhang Yueqiu, Wang Fulin, Yang Tong, Wei Wei
Department of Surgical Urology, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, 610041, China.
Discov Oncol. 2025 Jul 18;16(1):1368. doi: 10.1007/s12672-025-03197-5.
Adenoid cystic carcinoma (ACC) is a rare head and neck tumor with low incidence, characterized by local recurrence and early metastasis following surgical treatment. The common sites of metastasis for this cancer are typically the lungs, liver, brain, and bone, while metastasis to the kidneys is rare. This article reports a case of renal metastasis in a patient with adenoid cystic carcinoma of the maxillary sinus, occurring 16 years after surgery. The patient was a 34-year-old female with intermittent right lower abdominal pain for five months. She was diagnosed with maxillary sinus ACC 16 years ago and was treated surgically with adjuvant radiotherapy three times without regular follow-up. The patient underwent a robotic-assisted unilateral nephrectomy, and pathological examination confirmed the diagnosis of renal metastasis from adenoid cystic carcinoma. Postoperatively, the patient's abdominal pain resolved, and she was discharged on the fifth day with instructions for regular follow-up. During her first follow-up nine months later, she reported no discomfort and confirmed a smooth recovery. This case highlights the potential for late recurrence of adenoid cystic carcinoma, underscoring the importance of long-term follow-up and vigilant monitoring, even after successful initial treatment. Continued surveillance and refinement of treatment strategies are crucial for managing this challenging malignancy.
腺样囊性癌（ACC）是一种罕见的头颈部肿瘤，发病率较低，其特征是手术治疗后易发生局部复发和早期转移。这种癌症常见的转移部位通常是肺、肝、脑和骨，而转移至肾脏则较为罕见。本文报道了1例上颌窦腺样囊性癌患者术后16年发生肾转移的病例。该患者为34岁女性，间断性右下腹痛5个月。16年前她被诊断为上颌窦ACC，接受了手术治疗并辅助放疗3次，但未进行规律随访。患者接受了机器人辅助下单侧肾切除术，病理检查确诊为腺样囊性癌肾转移。术后，患者腹痛缓解，于术后第5天出院，并被告知要定期随访。9个月后的首次随访中，她表示无不适，证实恢复顺利。该病例凸显了腺样囊性癌晚期复发的可能性，强调了即使初始治疗成功后长期随访和密切监测的重要性。持续的监测和治疗策略的优化对于管理这种具有挑战性的恶性肿瘤至关重要。
