Castro Antonio G B, Polini Alessandro, Azami Zohal, Leeuwenburgh Sander C G, Jansen John A, Yang Fang, van den Beucken Jeroen J J P
Department of Biomaterials, Radboudumc, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands.
Department of Biomaterials, Radboudumc, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands.
J Mech Behav Biomed Mater. 2017 Jul;71:286-294. doi: 10.1016/j.jmbbm.2017.03.027. Epub 2017 Mar 28.
Calcium phosphate cements (CPCs) are biocompatible, resorbable, injectable and osteoconductive. Those properties render such materials suitable for applications where bone repair and regeneration is required However, their brittle nature limits their application only to non-load-bearing applications. The incorporation of long polymeric fibers can improve the mechanical properties of CPCs, but aggregation is a major problem. Instead, short polymeric fillers can be easily dispersed in the cement matrix, but their reinforcing effect has not been studied yet. In this study, continuous poly--lactic acid fibers (PLLA) with a smooth or porous surface morphology were prepared by electrospinning. PLLA micro-fillers were developed, by means of an aminolysis process, and added to α-TCP or α-TCP/PLGA-based cements. Micro-filler distribution as well as the morphology, cohesiveness, setting times and mechanical properties were evaluated. PLLA micro-fillers were homogeneously dispersed throughout the cement while the handling properties were not significantly affected. A decrease in the initial setting times was observed when PLLA was added, while the mechanical properties were comparable to those of the α-TPC or α-TCP/PLGA compositions.
磷酸钙骨水泥（CPCs）具有生物相容性、可吸收性、可注射性和骨传导性。这些特性使此类材料适用于需要骨修复和再生的应用。然而，它们的脆性限制了其仅适用于非承重应用。长聚合物纤维的加入可以改善CPCs的机械性能，但团聚是一个主要问题。相反，短聚合物填料可以很容易地分散在水泥基体中，但其增强效果尚未得到研究。在本研究中，通过静电纺丝制备了具有光滑或多孔表面形态的连续聚乳酸纤维（PLLA）。通过氨解工艺制备了PLLA微填料，并将其添加到α-TCP或α-TCP/PLGA基骨水泥中。评估了微填料的分布以及形态、内聚性、凝固时间和机械性能。PLLA微填料均匀地分散在整个骨水泥中，而操作性能没有受到显著影响。添加PLLA时观察到初始凝固时间缩短，而机械性能与α-TPC或α-TCP/PLGA组合物相当。
