Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands.
Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands; CAM Bioceramics B. V., Zernikedreef 6, Leiden 2333 CL, the Netherlands.
J Mech Behav Biomed Mater. 2019 Feb;90:472-483. doi: 10.1016/j.jmbbm.2018.11.003. Epub 2018 Nov 3.
Calcium phosphate cements (CPCs) are frequently used as synthetic bone substitute, but their intrinsic low fracture toughness impedes their application in highly loaded skeletal sites. However, fibers can be used to reduce the brittleness of these CPCs provided that the affinity between the fibers and cement matrix facilitates the transfer of loads from the matrix to the fibers. The aim of the present work was to improve the interface between hydrophobic polylactic acid (PLA) microfibers and hydrophilic CPC. To this end, calcium-binding alendronate groups were conjugated onto the surface of PLA microfibers via different strategies to immobilize a tunable amount of alendronate onto the fiber surface. CPCs reinforced with PLA fibers revealed toughness values which were up to 50-fold higher than unreinforced CPCs. Nevertheless, surface functionalization of PLA microfibers with alendronate groups did not improve the mechanical properties of fiber-reinforced CPCs.
磷酸钙骨水泥（CPCs）常被用作合成骨替代物，但由于其内在的低断裂韧性，限制了其在高负荷骨骼部位的应用。然而，纤维可以用来降低这些 CPC 的脆性，只要纤维和水泥基质之间的亲和力有利于将基质中的负载转移到纤维上。本工作旨在改善疏水性聚乳酸（PLA）微纤维与亲水性 CPC 之间的界面。为此，通过不同的策略将钙结合物阿仑膦酸盐基团接枝到 PLA 微纤维表面上，以将可调节量的阿仑膦酸盐固定在纤维表面上。与未增强的 CPC 相比，用 PLA 纤维增强的 CPC 的韧性值提高了高达 50 倍。然而，用阿仑膦酸盐基团对 PLA 微纤维进行表面功能化并没有改善纤维增强 CPC 的力学性能。
