Singh Sareena, Resnick Kimberly E
From the Department of OB/GYN, Division of Gynecologic Oncology, MetroHealth Medical Center, Cleveland, Ohio.
South Med J. 2017 Apr;110(4):265-269. doi: 10.14423/SMJ.0000000000000633.
In patients with Lynch syndrome, gynecologic cancer often can be the first presenting malignancy. In this review, we summarize the genetics of Lynch syndrome and review the various modalities of identifying patients at risk for this syndrome. The clinical characteristics of Lynch-associated endometrial cancer and screening and risk-reducing strategies also are described.
在林奇综合征患者中，妇科癌症往往可能是首个出现的恶性肿瘤。在本综述中，我们总结了林奇综合征的遗传学，并回顾了识别该综合征高危患者的各种方法。还描述了林奇综合征相关子宫内膜癌的临床特征以及筛查和降低风险的策略。
