Luo Fei, Guo Yuan, Ruan Gui-Yun, Peng Ran, Li Xiang-Ping
Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
Lipids Health Dis. 2017 Apr 4;16(1):72. doi: 10.1186/s12944-017-0463-0.
Estrogen had been found to be negatively associated with serum triglyceride (TG) levels. Apolipoprotein A5 (APOA5), a novel member of apolipoprotein family, was reported to have a strong ability to decrease serum concentrations of TG. Clinical data found concentrations of APOA5 were higher in woman than that in men, and the negative relationship between APOA5 and TG levels was more significant in woman. These suggests APOA5 may involve in estrogen actions. Therefore, we hypothesize estrogen up-regulates serum concentrations of APOA5 and subsequently decreases serum TG levels. We will design the following experiments to test this hypothesis. (1) We will treat wild and APOA5-defeted ovariectomized hamster with or without estrogen to examine if estrogen could up-regulate concentrations of APOA5 and decrease TG levels. (2) We will treat HepG2 cells with estrogen and investigate the possible mechanisms.
雌激素已被发现与血清甘油三酯（TG）水平呈负相关。载脂蛋白A5（APOA5）是载脂蛋白家族的一个新成员，据报道它具有强大的降低血清TG浓度的能力。临床数据发现，女性体内APOA5的浓度高于男性，且APOA5与TG水平之间的负相关关系在女性中更为显著。这些表明APOA5可能参与雌激素的作用。因此，我们假设雌激素上调血清APOA5浓度，随后降低血清TG水平。我们将设计以下实验来验证这一假设。（1）我们将用或不用雌激素处理野生型和APOA5基因敲除的去卵巢仓鼠，以检查雌激素是否能上调APOA5浓度并降低TG水平。（2）我们将用雌激素处理HepG2细胞并研究其可能的机制。
