Mousa Suzan Omar, Sayed Samira Zein, Moussa Mahmoud Mohammed, Hassan Ahmed Hamdy
Department of Pediatrics, Faculty of Medicine, Minia University, El-Minya, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Minia University, El-Minya, Egypt.
BMC Endocr Disord. 2017 Apr 4;17(1):23. doi: 10.1186/s12902-017-0174-6.
Many studies indicated that mean platelet volume (MPV) and platelet distribution width (PDW) may be valuable in the diagnosis and management of clinical disorders; also, serum butyrylcholinesterase activity (BChE) was suggested to be linked to systemic inflammation and oxidative stress. Limited studies measured these readily available markers in children with diabetic ketoacidosis (DKA). Our objectives were to measure MPV, PDW and BChE in children with DKA; and to assess if any of these markers reflects the severity of DKA.
Our study included: 30 children with DKA (DKA group), 30 diabetic children (Non-DKA group) and 30 apparently healthy children (control group). MPV, PDW and BChE were measured in all children. Additional blood samples were withdrawn from the DKA group to assess these markers at discharge from hospital.
MPV, PDW and BChE were significantly altered in the DKA group than the other two groups; and their levels improved significantly at discharge of the DKA group (p < 0.05). The three markers were found to equally to predict the presence of DKA, but MPV was the most suitable risk marker for DKA diagnosis (OR = 4.251, CI 95% =1.463-12.351, p = 0.003). Regarding their relation with DKA severity, they did not correlate significantly with arterial PH or serum HCO3 (p > 0.05).
DKA in children is associated with changes in MPV, PDW and BChE activity, which improve after resolution of the condition. Elevated MPV can be a suitable risk marker for DKA. None of the studied markers correlated with the severity of DKA.
许多研究表明，平均血小板体积（MPV）和血小板分布宽度（PDW）可能对临床疾病的诊断和管理具有重要价值；此外，血清丁酰胆碱酯酶活性（BChE）被认为与全身炎症和氧化应激有关。有限的研究对糖尿病酮症酸中毒（DKA）患儿的这些易于获得的指标进行了测量。我们的目的是测量DKA患儿的MPV、PDW和BChE；并评估这些指标是否能反映DKA的严重程度。
我们的研究包括：30例DKA患儿（DKA组）、30例糖尿病患儿（非DKA组）和30例健康儿童（对照组）。对所有儿童测量MPV、PDW和BChE。从DKA组额外采集血样，以评估出院时的这些指标。
与其他两组相比，DKA组的MPV、PDW和BChE有显著变化；DKA组出院时这些指标水平显著改善（p < 0.05）。发现这三个指标同样能预测DKA的存在，但MPV是DKA诊断中最合适的风险指标（OR = 4.251，95%CI = 1.463 - 12.351，p = 0.003）。关于它们与DKA严重程度的关系，它们与动脉血pH或血清HCO3无显著相关性（p > 0.05）。
儿童DKA与MPV、PDW和BChE活性变化有关，病情缓解后这些指标会改善。MPV升高可能是DKA的合适风险指标。所研究的指标均与DKA的严重程度无关。
