Eberwein P, Reinhard T
Klinik für Augenheilkunde, Uniklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
Ophthalmologe. 2017 Apr;114(4):318-326. doi: 10.1007/s00347-017-0463-5.
Reconstruction of the limbal stem cell niche in patients with limbal stem cell insufficiency remains one of the most challenging tasks in the treatment of ocular surface diseases. Ex vivo expansion of limbal stem cells still has potential for optimization despite positive reports in centers worldwide. New biomaterials as well as alternative cell sources for the reconstruction of the limbal stem cell niche have been published in recent years. The aim of this review is to provide insight into new biomaterials and cell sources which may find their way into clinical routine in the upcoming decades.
对于角膜缘干细胞功能不全患者的角膜缘干细胞微环境重建，仍然是眼表疾病治疗中最具挑战性的任务之一。尽管全球各中心均有阳性报告，但角膜缘干细胞的体外扩增仍有优化的潜力。近年来，已发表了用于重建角膜缘干细胞微环境的新型生物材料以及替代细胞来源。本综述的目的是深入探讨新型生物材料和细胞来源，它们可能在未来几十年进入临床常规应用。
