Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Electrical and Electronic Engineering, Yonsei University, Seoul, Korea.
J Magn Reson Imaging. 2017 Aug;46(2):528-536. doi: 10.1002/jmri.25553. Epub 2016 Nov 11.
To enhance the visibility of nigrosome 1 in substantia nigra, which has recently been suggested as an imaging biomarker for Parkinson's disease (PD) at 3T magnetic resonance imaging (MRI).
The substantia nigra structure was visualized at 3T MRI using multiecho susceptibility map-weighted imaging (SMWI) in 15 healthy volunteers and 6 patients with Parkinson's disease (PD). The visibility of nigrosome 1 was further enhanced by acquiring data in an oblique-coronal imaging plane at a high spatial resolution (0.5 × 0.5 × 1.0 mm ). To compare the visibility, the contrast-to-noise ratios (CNR) of the nigrosome 1 structure relative to the neighboring substantia nigra structure were evaluated in the SMWI and other conventional susceptibility contrast images (magnitude, frequency, quantitative susceptibility map [QSM] and susceptibility-weighted image).
In healthy volunteers, the CNRs of the nigrosome 1 structure were 1.04 ± 0.38, 0.84 ± 0.32, 1.04 ± 0.40, 0.86 ± 0.41, and 1.45 ± 0.48 for magnitude, frequency, quantitative susceptibility map, susceptibility-weighted image, and SMWI, respectively. Compared to conventional susceptibility contrast images, the SMWI method significantly improved the CNR of nigrosome 1 (P = 0.014 for magnitude, P = 0.030 for QSM, and P < 0.001 for frequency and SWI, respectively). The magnetic susceptibility difference between nigrosome 1 and neighboring substantia nigra structures was 0.037 ± 0.016 ppm (measured in QSM, P < 0.001) in healthy volunteers. In the PD patients, the visibility of the nigrosome 1 structures was reduced.
The SMWI method enhances the visibility of nigrosome 1 structures at 3T MRI when compared to conventional susceptibility contrast images.
3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:528-536.
提高黑质 1 号在磁共振成像（MRI）中的可视性，该部位最近被提议作为帕金森病（PD）的成像生物标志物。
使用多回波磁化率图加权成像（SMWI）在 15 名健康志愿者和 6 名帕金森病（PD）患者的 3T MRI 上观察黑质结构。通过在高空间分辨率（0.5×0.5×1.0mm）的斜冠状成像平面上获取数据，进一步增强黑质 1 号的可视性。为了进行比较，在 SMWI 和其他常规磁化率对比图像（幅度、频率、定量磁化率图[QSM]和磁化率加权图像）中评估黑质 1 号结构相对于相邻黑质结构的对比噪声比（CNR）。
在健康志愿者中，黑质 1 号结构的 CNR 分别为 1.04±0.38、0.84±0.32、1.04±0.40、0.86±0.41 和 1.45±0.48，用于幅度、频率、定量磁化率图、磁化率加权图像和 SMWI。与常规磁化率对比图像相比，SMWI 方法显著提高了黑质 1 号的 CNR（幅度为 P=0.014，QSM 为 P=0.030，频率和 SWI 分别为 P<0.001）。黑质 1 号和相邻黑质结构之间的磁化率差异为 0.037±0.016ppm（在 QSM 中测量，P<0.001）。在 PD 患者中，黑质 1 号结构的可见度降低。
与常规磁化率对比图像相比，SMWI 方法可提高 3T MRI 中黑质 1 号结构的可视性。
3 级技术功效：第 2 阶段。J. MAGN. RESON. IMAGING 2017；46：528-536.
