Unit of Neurology and Neurometabolic Disorders, Department of Medical, Surgical and Neurological Sciences, University of Siena, Viale Bracci 1, 53100, Siena, Italy.
Stroke Unit, NEUROFARBA Department, University of Florence, Florence, Italy.
Neurol Sci. 2017 Jul;38(7):1333-1336. doi: 10.1007/s10072-017-2900-2. Epub 2017 Apr 4.
Besides its well known function on bone metabolism, vitamin D role in cerebrovascular pathologies including cerebral small vessel disease has been confirmed by recent meta-analysis. In this study, we measured vitamin D levels in 56 Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients (mean age 49.9) with no or minimal disability (modified Ranking Score, mRS ≤2) and in 56 age, sex and seasonality matched healthy controls. History of ischemic events was recorded and cognitive functions were assessed using the Mini-Mental State Examination. White matter hyperintensities on brain T2-weighted magnetic resonance images were classified according to a modified Fazekas scale. Comparison of vitamin D levels between patients and controls showed significant lower values (p < 0.05) in no-to-mild CADASIL patients and a higher number of subjects with severe deficiency [25(OH)D <10 ng/ml]. Vitamin D levels did not correlate with vascular risk factors, clinical data or Fazekas score. The role of vitamin D is worth to be further explored in prospective studies.
除了其在骨代谢方面的众所周知的功能外，最近的荟萃分析证实了维生素 D 在包括脑小血管疾病在内的脑血管病中的作用。在这项研究中，我们测量了 56 名无或轻度残疾（改良 Rankin 评分，mRS≤2）的常染色体显性脑动脉病伴皮质下梗死和白质脑病（CADASIL）患者（平均年龄 49.9 岁）和 56 名年龄、性别和季节性匹配的健康对照者的维生素 D 水平。记录了缺血性事件的病史，并使用简易精神状态检查评估了认知功能。脑 T2 加权磁共振图像上的脑白质高信号按照改良 Fazekas 量表进行分类。患者和对照组之间维生素 D 水平的比较显示，无至轻度 CADASIL 患者的维生素 D 水平显著降低（p<0.05），且严重缺乏的患者人数更多[25（OH）D<10ng/ml]。维生素 D 水平与血管危险因素、临床数据或 Fazekas 评分无关。维生素 D 的作用值得在前瞻性研究中进一步探讨。
