Kohno Daisuke
Advanced Scientific Research Leaders Development Unit, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8512, Japan.
Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371-8512, Japan.
J Physiol Sci. 2017 Jul;67(4):459-465. doi: 10.1007/s12576-017-0535-y. Epub 2017 Apr 4.
The hypothalamic feeding center plays an important role in energy homeostasis. The feeding center senses the systemic energy status by detecting hormone and nutrient levels for homeostatic regulation, resulting in the control of food intake, heat production, and glucose production and uptake. The concentration of glucose is sensed by two types of glucose-sensing neurons in the feeding center: glucose-excited neurons and glucose-inhibited neurons. Previous studies have mainly focused on glucose metabolism as the mechanism underlying glucose sensing. Recent studies have indicated that receptor-mediated pathways also play a role in glucose sensing. This review describes sweet taste receptors in the hypothalamus and explores the role of sweet taste receptors in energy homeostasis.
下丘脑进食中枢在能量稳态中发挥着重要作用。进食中枢通过检测激素和营养物质水平来感知全身能量状态，以进行稳态调节，从而控制食物摄入、产热以及葡萄糖的生成和摄取。进食中枢中的两种葡萄糖感应神经元可感知葡萄糖浓度：葡萄糖兴奋神经元和葡萄糖抑制神经元。以往的研究主要集中在葡萄糖代谢作为葡萄糖感应的潜在机制。最近的研究表明，受体介导的途径在葡萄糖感应中也发挥作用。这篇综述描述了下丘脑中的甜味受体，并探讨了甜味受体在能量稳态中的作用。
