Gazdar A F, Linnoila R I
NCI-Navy Medical Oncology Branch, Bethesda, MD 20814.
Semin Oncol. 1988 Jun;15(3):215-25.
While the basic classification of lung cancer has not altered drastically over the course of the last several years, histologic criteria have undergone a slow, progressive evolution. Input from biological studies has aided the subtyping of some tumors, especially SCLC, and helped delineate the importance of the accurate typing of NSCLC. Newer technological advances, especially in molecular biology, and application of established immunohistochemical techniques using newly generated antibodies are beginning to impact on diagnosis and typing. The evolution and application of clinical protocols directed to specific types or subtypes of lung cancer will provide an even greater impetus to these studies.
尽管在过去几年里肺癌的基本分类没有发生重大改变，但组织学标准却经历了缓慢而渐进的演变。生物学研究的成果有助于某些肿瘤的亚型分类，尤其是小细胞肺癌（SCLC），并有助于明确非小细胞肺癌（NSCLC）准确分型的重要性。更新的技术进步，尤其是分子生物学领域的进步，以及使用新产生抗体的既定免疫组化技术的应用，正开始对诊断和分型产生影响。针对肺癌特定类型或亚型的临床方案的演变和应用将为这些研究提供更大的推动力。
