Ferri Raffaele, Rundo Francesco, Silvani Alessandro, Zucconi Marco, Aricò Debora, Bruni Oliviero, Lanuzza Bartolo, Ferini-Strambi Luigi, Manconi Mauro
Department of Neurology, IRCCS Oasi, Troina, Italy.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
J Sleep Res. 2017 Oct;26(5):602-605. doi: 10.1111/jsr.12529. Epub 2017 Apr 4.
Periodic leg movements during sleep (PLMS) are sequences of ≥4 motor events with intermovement intervals (IMI) of 10-90 s. PLMS are a supportive diagnostic criterion for restless legs syndrome (RLS) and entail cardiac activation, particularly when associated with arousal. RLS patients also over-express short-interval leg movements during sleep (SILMS), which have IMI <10 s and are organized mainly in sequences of two movements (doublets). We tested whether the cardiac activation associated with SILMS doublets differs from that associated with PLMS in a sample of 25 RLS patients. We analysed time-series of R-R intervals synchronized to the onset of SILMS doublets or PLMS that entailed an arousal during non-rapid eye movement (NREM) sleep. We assessed cardiac activation based on the R-R interval decrease with respect to baseline during NREM sleep without leg movements. We found that the duration of the R-R interval decrease with SILMS doublets was significantly longer than that with PLMS, whereas the maximal decrease in R-R interval was similar. Scoring SILMS in RLS patients may therefore be relevant from a cardiac autonomic perspective.
睡眠期周期性腿部运动（PLMS）是一系列≥4次的运动事件，其运动间隔（IMI）为10 - 90秒。PLMS是不宁腿综合征（RLS）的一项辅助诊断标准，会引起心脏激活，尤其是与觉醒相关时。RLS患者在睡眠中还会过度表达短间隔腿部运动（SILMS），其IMI <10秒，主要以两个运动序列（双峰）形式出现。我们在25例RLS患者样本中测试了与SILMS双峰相关的心脏激活是否与PLMS相关的心脏激活不同。我们分析了与SILMS双峰或PLMS发作同步的R-R间期时间序列，这些发作发生在非快速眼动（NREM）睡眠期间并伴有觉醒。我们根据NREM睡眠期间无腿部运动时R-R间期相对于基线的减少来评估心脏激活。我们发现，与SILMS双峰相关的R-R间期减少持续时间明显长于与PLMS相关的，而R-R间期的最大减少相似。因此，从心脏自主神经角度来看，对RLS患者的SILMS进行评分可能具有重要意义。
