Yang Haijun, Yang Min, Wang Yan, Huang Xing
1 Department of Preventive Medicine, College of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan, P.R. China.
Tumour Biol. 2017 Apr;39(4):1010428317694564. doi: 10.1177/1010428317694564.
We read with great interest the paper entitled "Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis" published online by Sun et al. Their results suggest that interferon gamma ( IFNG) gene +874 T/A polymorphism might contribute to women's susceptibility to cervical cancer. They also found that IFNG +874 T/A polymorphism is associated with increased cervical cancer risk in Asian female population. The result is encouraging. Nevertheless, several key issues are worth noticing. We re-evaluate the association between IFNG +874 T/A polymorphism and cervical cancer risk by performing an updated meta-analysis based on 2777 cases and 2542 controls of 11 studies. We found that IFNG +874 T/A polymorphism was not significantly associated with cervical cancer risk in overall population. We also observed that the polymorphism was associated with enhanced cervical cancer risk in Asian population and was relevant to increased squamous cell cervical cancer risk.
我们饶有兴趣地阅读了Sun等人在线发表的题为“干扰素γ +874 T/A多态性增加宫颈癌风险：一项荟萃分析的证据”的论文。他们的结果表明，干扰素γ（IFNG）基因 +874 T/A多态性可能与女性宫颈癌易感性有关。他们还发现，IFNG +874 T/A多态性与亚洲女性人群宫颈癌风险增加有关。这一结果令人鼓舞。然而，几个关键问题值得注意。我们通过对11项研究中的2777例病例和2542例对照进行更新的荟萃分析，重新评估了IFNG +874 T/A多态性与宫颈癌风险之间的关联。我们发现，IFNG +874 T/A多态性与总体人群的宫颈癌风险无显著关联。我们还观察到，该多态性与亚洲人群宫颈癌风险增加有关，且与鳞状细胞宫颈癌风险增加相关。
