Sha Huan-Huan, Wang Dan-Dan, Chen Dan, Liu Si-Wen, Wang Zhen, Yan Da-Li, Dong Shu-Chen, Feng Ji-Feng
1 Department of Chemotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
2 The First Clinical School of Nanjing Medical University, Nanjing, China.
Tumour Biol. 2017 Apr;39(4):1010428317697575. doi: 10.1177/1010428317697575.
MicroRNAs are small noncoding RNAs which regulate gene expressions at post-transcriptional level by binding to the 3'-untranslated region of target messenger RNAs. Growing evidences highlight their pivotal roles in various biological processes of human cancers. Among them, miR-138, generating from two primary transcripts, pri-miR-138-1 and pri-miR-138-2, expresses aberrantly in different cancers and is extensively studied in cancer network. Importantly, studies have shown that miR-138 acts as a tumor suppressor by targeting many target genes, which are related to proliferation, apoptosis, invasion, and migration. Additionally, some researches also discover that miR-138 can sensitize tumors to chemotherapies. In this review, we summarize the expression of miR-138 on regulatory mechanisms and tumor biological processes, which will establish molecular basis on the usage of miR-138 in clinical applications in the future.
微小RNA是一类小的非编码RNA，它们通过与靶信使RNA的3'非翻译区结合，在转录后水平调节基因表达。越来越多的证据表明它们在人类癌症的各种生物学过程中起着关键作用。其中，由两个初级转录本pri-miR-138-1和pri-miR-138-2产生的miR-138在不同癌症中表达异常，并在癌症网络中得到广泛研究。重要的是，研究表明miR-138通过靶向许多与增殖、凋亡、侵袭和迁移相关的靶基因发挥肿瘤抑制作用。此外，一些研究还发现miR-138可以使肿瘤对化疗敏感。在这篇综述中，我们总结了miR-138在调控机制和肿瘤生物学过程中的表达，这将为未来miR-138在临床应用中的使用奠定分子基础。
