Gao Yanping, Feng Bing, Han Siqi, Zhang Kai, Chen Jing, Li Chen, Wang Rui, Chen Longbang
Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Cell Physiol Biochem. 2016;38(2):427-48. doi: 10.1159/000438641. Epub 2016 Feb 1.
Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progression. As one important member of the miR-200 family, microRNA (miR)-141 is aberrantly expressed in many human malignant tumors, participating in various cellular processes including epithelial-mesenchymal transition (EMT), proliferation, migration, invasion, and drug resistance. In the present review, we briefly describe the mechanisms underlying miR-141-mediated tumorigenesis and the possible future of miR-141 as a potential diagnostic and prognostic parameter as well as therapeutic target in clinical applications.
癌症仍然是人类健康受损的最具威胁性的原因之一，肿瘤发生的机制尚未完全明确。微小RNA（miRNA）是一类内源性的小（18∼25个核苷酸）非编码RNA，它们通过直接结合靶信使RNA（mRNA）的3'非翻译区（3'-UTR）来负调控基因表达。越来越多的证据表明miRNA谱异常，并证实它们参与肿瘤的起始和进展。作为miR-200家族的重要成员之一，微小RNA（miR）-141在许多人类恶性肿瘤中异常表达，参与包括上皮-间质转化（EMT）、增殖、迁移、侵袭和耐药性在内的各种细胞过程。在本综述中，我们简要描述了miR-141介导肿瘤发生的机制，以及miR-141作为潜在的诊断和预后参数以及临床应用中的治疗靶点的可能前景。
