Rosonina Emanuel, Akhter Akhi, Dou Yimo, Babu John, Sri Theivakadadcham Veroni S
a Department of Biology , York University , Toronto , ON , Canada.
Transcription. 2017 Aug 8;8(4):220-231. doi: 10.1080/21541264.2017.1311829. Epub 2017 Apr 5.
Transcription factors (TFs) are among the most frequently detected targets of sumoylation, and effects of the modification have been studied for about 200 individual TFs to date. TF sumoylation is most often associated with reduced target gene expression, which can be mediated by enhanced interactions with corepressors or by interference with protein modifications that promote transcription. However, recent studies show that sumoylation also regulates gene expression by controlling the levels of TFs that are associated with chromatin. SUMO can mediate this by modulating TF DNA-binding activity, promoting clearance of TFs from chromatin, or indirectly, by influencing TF abundance or localization.
转录因子（TFs）是最常被检测到的SUMO化修饰靶点之一，迄今为止，已对约200种单个转录因子的修饰效应进行了研究。转录因子的SUMO化修饰通常与靶基因表达降低有关，这可能是通过与共抑制因子的相互作用增强或通过干扰促进转录的蛋白质修饰来介导的。然而，最近的研究表明，SUMO化修饰还通过控制与染色质相关的转录因子水平来调节基因表达。SUMO可以通过调节转录因子与DNA的结合活性、促进转录因子从染色质上清除，或间接影响转录因子的丰度或定位来介导这一过程。
