Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
Cell Mol Life Sci. 2021 Mar;78(6):2641-2664. doi: 10.1007/s00018-020-03723-4. Epub 2021 Jan 16.
Across all species, transcription factors (TFs) are the most frequent targets of SUMOylation. The effect of SUMO conjugation on the functions of transcription factors has been extensively studied in animal systems, with over 200 transcription factors being documented to be modulated by SUMOylation. This has resulted in the establishment of a number of paradigms that seek to explain the mechanisms by which SUMO regulates transcription factor functions. For instance, SUMO has been shown to modulate TF DNA binding activity; regulate both localization as well as the abundance of TFs and also influence the association of TFs with chromatin. With transcription factors being implicated as master regulators of the cellular signalling pathways that maintain phenotypic plasticity in all organisms, in this review, we will discuss how SUMO mediated regulation of transcription factor activity facilitates molecular pathways to mount an appropriate and coherent biological response to environmental cues.
在所有物种中，转录因子（TFs）是 SUMO 化的最常见靶标。SUMO 缀合对转录因子功能的影响已在动物系统中得到广泛研究，已有超过 200 种转录因子被证实可通过 SUMO 化进行调节。这导致了一些范例的建立，旨在解释 SUMO 调节转录因子功能的机制。例如，SUMO 已被证明可以调节 TF 的 DNA 结合活性；调节 TF 的定位和丰度，也影响 TF 与染色质的结合。由于转录因子被认为是维持所有生物体表型可塑性的细胞信号通路的主要调节剂，在这篇综述中，我们将讨论 SUMO 介导的转录因子活性调节如何促进分子途径，以对环境线索做出适当和一致的生物学反应。
