Ornek Firdevs, Acar Damla Erginturk, Acar Ugur, Ozdemir Ozdemir, Atilgan Hasan Ikbal, Yumusak Nihat, Ozgermen Basak Boztok
Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
Department of Ophthalmology, Zekai Tahir Burak Women's Health Training and Research Hospital, Ankara, Turkey.
Arq Bras Oftalmol. 2017 Jan-Feb;80(1):35-40. doi: 10.5935/0004-2749.20170010.
: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats.
: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), which received a single dose of 3 mCi of 131I and 1 mL of physiologic saline containing zinc sulfate at a concentration of 10 mg/kg concentration for 7 days by gastric gavage. All rats underwent tear function tests before and 1 week after RAI administration. About 1 week after irradiation, half of the animals in each group were sacrificed and the extraorbital lacrimal glands were removed for histopathological examination. The remaining animals of the groups underwent the same procedures at 8 weeks after irradiation.
: In the RAI and zinc groups, the mean tear production was 3.75 ± 1.55 and 3.65 ± 1.53 mm at baseline, 2.10 ± 1.07 and 3.30 ± 1.34 mm at week 1 (p=0.004), and 3.22 ± 1.48 and 3.50 ± 1.78 mm at week 8, respectively; further, the mean corneal fluorescein staining scores were 4.65 ± 2.16 and 4.80 ± 2.21 points at baseline, 7.85 ± 1.90 and 5.45 ± 2.06 points at week 1 (p=0.001), and 5.44 ± 2.13 and 4.90 ± 2.08 at week 8, respectively. The histopathological changes in rat lacrimal glands at weeks 1 and 8 were consistent with the tear function test results.
: Zinc treatment seems to be protective against RAI-induced lacrimal gland damage of rats, particularly in the acute period.
研究锌给药对大鼠放射性碘（RAI）诱导的泪腺损伤的短期（1周）和长期（8周）保护作用。
将40只大鼠分为两组：RAI组（n = 20），通过胃管给予单剂量3 mCi的131I和1 mL生理盐水，持续7天；锌组（n = 20），通过胃管给予单剂量3 mCi的131I和1 mL含10 mg/kg浓度硫酸锌的生理盐水，持续7天。所有大鼠在RAI给药前和给药后1周进行泪液功能测试。照射后约1周，每组一半的动物被处死，取出眶外泪腺进行组织病理学检查。两组其余动物在照射后8周进行相同的操作。
在RAI组和锌组中，基线时平均泪液分泌量分别为3.75±1.55和3.65±1.53 mm，第1周时分别为2.10±1.07和3.30±1.34 mm（p = 0.004），第8周时分别为3.22±1.48和3.50±1.78 mm；此外，基线时平均角膜荧光素染色评分为4.65±2.16和4.80±2.21分，第1周时分别为7.85±1.90和5.45±2.06分（p = 0.001），第8周时分别为5.44±2.13和4.90±2.08分。第1周和第8周大鼠泪腺的组织病理学变化与泪液功能测试结果一致。
锌治疗似乎对大鼠RAI诱导的泪腺损伤具有保护作用，尤其是在急性期。
