Department of Ophthalmology, Kastamonu Faculty of Medicine, Hacettepe University, Kazakistan Caddesi 90/7 Emek, 06500, Ankara, Turkey,
Ann Nucl Med. 2013 Dec;27(10):886-91. doi: 10.1007/s12149-013-0763-z. Epub 2013 Aug 27.
Radioiodine (RAI) is a well-known radionuclide which is used in vivo both for diagnostic and therapeutic purposes, particularly for the treatment of hyperthyroidism and thyroid cancer. Vitamin E is a well-known antioxidant vitamin. The aim of this study was to evaluate whether there was a protective effect of short-term vitamin E on RAI-induced lacrimal gland early damage in experimental animal models.
Twentyfour rats were randomly divided into two groups. The first group (RAI group) was administreted 3 mCi (131)I by gastric gavage and 1 mL physiological saline intraperitoneally. The second group (RAI + Vitamin E) was administrated 3 mCi (131)I by gastric gavage and 1 mL vitamin E intraperitoneally. After 24 h of the last dose being administered on the 7th day, the animals were decapitated. The lacrimal glands [Intraorbital (IG), extraorbital (EG) and harderian glands (HG)] of the rats were removed for histopathological examination.
Periductal and/or periacinar fibrosis in all lacrimal glands were observed to be statistically significantly less frequent in the RAI + Vitamin E group compared to the RAI group. The existence of the abnormal lobular pattern and peripheral basophilia and irregular nucleus shape in IG and in EG, the poorly defined acidophilic cell outline and periductal infiltration in IG and in HG were observed to be statistically significantly less frequent in the RAI + Vitamin E group than in the RAI group.
According to study results, histopathological examinations revealed that vitamin E protects rat lacrimal glands against RAI-related early damage.
放射性碘（RAI）是一种众所周知的放射性核素，用于体内诊断和治疗目的，特别是治疗甲状腺功能亢进症和甲状腺癌。维生素 E 是一种众所周知的抗氧化维生素。本研究旨在评估短期维生素 E 是否对实验动物模型中的放射性碘诱导的泪腺早期损伤有保护作用。
24 只大鼠随机分为两组。第一组（RAI 组）经胃管给予 3mCi（131）I 和 1mL 生理盐水腹腔内注射。第二组（RAI+维生素 E 组）经胃管给予 3mCi（131）I 和 1mL 维生素 E 腹腔内注射。第 7 天最后一次给药后 24 小时，处死动物。取出大鼠的泪腺[眶内（IG）、眶外（EG）和哈德腺（HG）]进行组织病理学检查。
与 RAI 组相比，RAI+维生素 E 组所有泪腺的导管周围和/或腺泡周围纤维化的发生率均显著降低。IG 和 EG 中异常小叶模式和周围嗜碱性、不规则核形状的存在，IG 和 HG 中酸性细胞轮廓和导管周围浸润的不明确性均显著降低。
根据研究结果，组织病理学检查显示维生素 E 可保护大鼠泪腺免受放射性碘相关的早期损伤。
