Zhu F Q, Du Z W, Bao Y D
First Hospital, Suzhou Medical College.
Zhonghua Zhong Liu Za Zhi. 1987 Nov;9(6):460-2, 21.
It has been demonstrated, by experiments, that DBc-AMP can induce biochemical and morphological changes in cultured glioma cells. In this paper, seven recurrent malignant glioma patients, who had received operation, radiotherapy and chemotherapy, were treated with DBc-AMP by injecting into the tumor feeding artery in 1 patient and directly into the tumor cavities in 6 patients. The results showed that although no improvement of symptoms was observed except the case by intraarterial injection, the IgG and IgA levels were elevated and tumor volume was reduced as shown by enhancement CT scan in 4 patients. It suggests that this method be a better adjuvant therapy for recurrent malignant gliomas.
实验已证明，二丁酰环磷腺苷钙（DBc - AMP）可诱导培养的胶质瘤细胞发生生化和形态学变化。本文中，7例接受过手术、放疗和化疗的复发性恶性胶质瘤患者接受了DBc - AMP治疗，其中1例通过向肿瘤供血动脉注射，6例直接注入肿瘤腔。结果显示，除动脉内注射的病例外，虽未观察到症状改善，但4例患者的IgG和IgA水平升高，增强CT扫描显示肿瘤体积减小。这表明该方法是复发性恶性胶质瘤较好的辅助治疗方法。
