Mitrani-Rosenbaum S, Gal D, Friedman M, Kitron N, Tsvieli R, Mordel N, Anteby S O
Department of Virology, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Eur J Cancer Clin Oncol. 1988 Apr;24(4):725-31. doi: 10.1016/0277-5379(88)90306-9.
Human papillomaviruses (HPVs) have been strongly associated with benign lesions of the genital tract (condylomata) and with genital cancer of the vulva and cervix. Since the incidence of these lesions in Israel is considered to be low, we have studied the presence of HPV 6, 11, 16 and 18 DNAs in benign, premalignant and malignant tissue samples or gynecological swabs of the lower genital tract. HPV sequences were detected in 48 out of 66 condylomatous lesions (72%), 5/11 grades I-II intraepithelial neoplasia (45%), 4/6 grade III intraepithelial neoplasia (carcinoma in situ) (66.6%) and 8/22 invasive carcinoma (36%). The latter included six cases of vulvar carcinoma which were all negative for HPV sequences. No additional HPV types could be detected in any of the tissue biopsies examined. HPV 18 DNA has been found in one vulvar condyloma where it persisted as an episomal molecule, this being the first report of that specific viral DNA in a condylomatous lesion. In all the benign and premalignant lesions containing HPV, the viral sequences were maintained in an episomal state. In two cases of invasive carcinoma, the HPV 16/18 related sequences were integrated in the cellular genome, but in five cases (three containing HPV 16/18 related DNAs and two containing HPV 6/11 related DNAs) the viral sequences were episomal. HPV 16/18 related sequences detected in one out of three cases of vaginal carcinoma were also found to be episomal. This data indicates that human papillomavirus sequences are indeed found in genital lesions of Israeli patients, although to a lesser extent than in other countries, especially for benign lesions and invasive carcinomas. Although HPVs may have a causative role in the development of genital lesions, also in this low tumor incidence area, other factors should be also considered in the etiology of these lesions.
人乳头瘤病毒（HPV）与生殖道良性病变（湿疣）以及外阴和宫颈癌密切相关。由于这些病变在以色列的发病率被认为较低，我们研究了HPV 6、11、16和18型DNA在下生殖道良性、癌前和恶性组织样本或妇科拭子中的存在情况。在66例湿疣病变中有48例（72%）检测到HPV序列，11例I-II级上皮内瘤变中有5例（45%），6例III级上皮内瘤变（原位癌）中有4例（66.6%），22例浸润癌中有8例（36%）。后者包括6例外阴癌，所有病例的HPV序列均为阴性。在所检查的任何组织活检中均未检测到其他HPV类型。在1例外阴湿疣中发现了HPV 18 DNA，它以游离分子形式持续存在，这是该特定病毒DNA在湿疣病变中的首次报道。在所有含有HPV的良性和癌前病变中，病毒序列均保持游离状态。在2例浸润癌中，HPV 16/18相关序列整合到了细胞基因组中，但在5例（3例含有HPV 16/18相关DNA，2例含有HPV 6/11相关DNA）中病毒序列是游离的。在3例阴道癌中的1例中检测到的HPV 16/18相关序列也被发现是游离的。这些数据表明，以色列患者的生殖器病变中确实存在人乳头瘤病毒序列，尽管程度低于其他国家，尤其是良性病变和浸润癌。尽管HPV可能在生殖器病变的发生中起致病作用，但在这个肿瘤发病率较低的地区，这些病变的病因中也应考虑其他因素。
