Sugase M, Moriyama S, Matsukura T
Department of Obstetrics and Gynecology, Nagano Red Cross Hospital, Japan.
J Med Virol. 1991 May;34(1):1-6. doi: 10.1002/jmv.1890340102.
Clinically diagnosed exophytic condylomatous lesions on the vulva (20 cases), vagina (5 cases), and cervix (9 cases) were examined pathologically, and human papillomavirus (HPV) types present in those lesions were identified by Southern blot hybridization analysis. All vulvar and vaginal lesions showed typical histopathological features of classical condylomata, and HPV 6 and 11 were found in 15 vulvar and 3 vaginal lesions and in 5 vulvar and 2 vaginal lesions, respectively. In 5 cervical lesions with typical condylomatous changes, HPV 6 or 11 was also detected; however, HPV 16 was found in 2 cases of cervical lesion surrounded by prominent intraepithelial neoplasia, and HPV 31 was found in 2 cases of slightly elevated lesion with intraepithelial neoplasia. These observations suggest that HPV 6 and 11 have the potency to induce the specific pathological changes, condylomatous, in any regions of the female lower genital tract.
对临床诊断为外阴（20例）、阴道（5例）和宫颈（9例）的外生性湿疣样病变进行病理检查，并通过Southern印迹杂交分析鉴定这些病变中存在的人乳头瘤病毒（HPV）类型。所有外阴和阴道病变均表现出典型的经典湿疣组织病理学特征，HPV 6和11分别在15例外阴病变和3例阴道病变以及5例外阴病变和2例阴道病变中被发现。在5例具有典型湿疣样改变的宫颈病变中也检测到HPV 6或11；然而，在2例伴有显著上皮内瘤变的宫颈病变中发现了HPV 16，在2例伴有上皮内瘤变的轻度隆起病变中发现了HPV 31。这些观察结果表明，HPV 6和11有能力在女性下生殖道的任何区域诱导湿疣样的特定病理变化。
