α干扰素治疗下生殖道上皮内瘤变：病例报告

Interferon-alpha in treatment of intraepithelial neoplasia of the lower genital tract: a case report.

作者信息

Slotman B J, Helmerhorst T J, Wijermans P W, Calame J J

机构信息

Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1988 Apr;27(4):327-33. doi: 10.1016/0028-2243(88)90046-9.

DOI:10.1016/0028-2243(88)90046-9

PMID:2838345

Abstract

A patient with persistent intraepithelial neoplasia of the vulva, vagina and cervix was treated with subcutaneous injections of interferon-alpha-2b. Previous surgical and laser procedures had failed. HPV subtype 16 was found in biopsies from all sites and an immunological screening was performed before and after therapy. Histologically proven regression of the intraepithelial neoplasia was seen at all sites, with a complete remission of the cervical lesions. The role of interferon in treatment of intraepithelial neoplasia is discussed.

摘要

一名患有外阴、阴道和宫颈持续性上皮内瘤变的患者接受了皮下注射α-2b干扰素的治疗。此前的手术和激光治疗均告失败。在所有部位的活检中均发现了16型人乳头瘤病毒（HPV），并在治疗前后进行了免疫筛查。所有部位的上皮内瘤变经组织学证实均有消退，宫颈病变完全缓解。本文讨论了干扰素在治疗上皮内瘤变中的作用。