Shinar S, Skornick-Rapaport A, Maslovitz S
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
J Perinatol. 2017 Jul;37(7):782-786. doi: 10.1038/jp.2017.43. Epub 2017 Apr 6.
To assess the efficacy of doubling the 30 mg dose of iron in women with iron deficiency anemia (IDA) in singleton pregnancies.
Prospective randomized controlled trial. Iron-deficient women were randomized during the second trimester to receive one or two capsules of daily iron supplement, containing 34 mg of ferrous sulfate, from 17 weeks until 6 weeks postpartum. The primary outcome was hemoglobin (Hgb) at 35 weeks. Secondary outcomes included ferritin at 35 weeks, Hgb during pregnancy and postpartum, birth weights, preterm birth rate, gastrointestinal side effects, intravenous iron administration and compliance.
In all, 160 women were randomized to receive one capsule and 164 received two capsules. Both groups had similar Hgb (10.1 g dl) and ferritin (9.3 and 9.4 ng l) at allocation. Hgb concentration in both groups was similar at 35 weeks (10.8 g dl). There were no significant differences in any of the secondary outcomes.
In IDA pregnant women, a single dose of iron is as effective as a double dose.
评估单胎妊娠缺铁性贫血（IDA）女性将铁剂剂量从30mg加倍的疗效。
前瞻性随机对照试验。缺铁女性在孕中期随机分组，从孕17周直到产后6周，每日服用1粒或2粒含铁补充剂胶囊，每粒含34mg硫酸亚铁。主要结局指标为孕35周时的血红蛋白（Hgb）。次要结局指标包括孕35周时的铁蛋白、孕期及产后的Hgb、出生体重、早产率、胃肠道副作用、静脉补铁及依从性。
总计160名女性被随机分配接受1粒胶囊，164名接受2粒胶囊。两组在分配时的Hgb（10.1g/dl）和铁蛋白（9.3和9.4ng/l）相似。两组在孕35周时的Hgb浓度相似（10.8g/dl）。任何次要结局指标均无显著差异。
在IDA孕妇中，单剂量铁剂与双剂量铁剂效果相同。
