Wang Kevin A, Wang Jia-Chi, Lin Cheng-Li, Tseng Chun-Hung
Division of General Surgery, Department of Surgery, Shin-Kong Memorial Hospital, Taipei, Taiwan.
School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
PLoS One. 2017 Apr 6;12(4):e0175370. doi: 10.1371/journal.pone.0175370. eCollection 2017.
The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD.
In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control cohort by randomly choosing 104269 people without FMS who were matched to the FMS patients by gender, age, and index year. All patients were free of PUD at the baseline. Cox proportional hazard regressions were performed to compute the hazard ratio of PUD after adjustment for demographic characteristics and comorbidities.
The prevalence of comorbidities was significantly higher in the FMS patients than in the controls. The incidence of PUD was 29.8 and 19.4 per 1000 person-years in the FMS and control cohorts, respectively. In addition, the FMS cohort exhibited a 1.40-fold higher risk of PUD (95% confidence interval = 1.35-1.45) compared with the control cohort. After control for confounding factors, the medications (selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and antidepressants) taken by the FMS patients did not increase the risk of PUD.
FMS patients exhibit a higher risk of PUD than that of patients without FMS.
纤维肌痛综合征（FMS）与消化性溃疡病（PUD）之间的相关性尚不清楚。因此，我们进行了一项队列研究，以调查FMS是否与PUD风险增加相关。
在本研究中，我们建立了一个FMS队列，其中包括2000年至2011年被诊断为FMS的26068名20岁以上的患者。此外，我们通过随机选择104269名无FMS的人建立了一个对照队列，这些人与FMS患者在性别、年龄和索引年份上相匹配。所有患者在基线时均无PUD。进行Cox比例风险回归以计算在调整人口统计学特征和合并症后PUD的风险比。
FMS患者的合并症患病率显著高于对照组。FMS队列和对照队列中PUD的发病率分别为每1000人年29.8例和19.4例。此外，与对照队列相比，FMS队列发生PUD的风险高1.40倍（95%置信区间=1.35-1.45）。在控制混杂因素后，FMS患者服用的药物（选择性5-羟色胺再摄取抑制剂、5-羟色胺-去甲肾上腺素再摄取抑制剂和抗抑郁药）并未增加PUD的风险。
FMS患者发生PUD的风险高于无FMS的患者。
