消化性溃疡与精神分裂症的关联：一项基于人群的研究。
The association of peptic ulcer and schizophrenia: a population-based study.
作者信息
Liao Chun-Hui, Chang Chen-Shu, Chang Shih-Ni, Muo Chih-Hsin, Lane Hsien-Yuan, Sung Fung-Chang, Kao Chia-Hung
机构信息
Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan; Department of Medical Laboratory Science and Biotechnology, and Medical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan.
出版信息
J Psychosom Res. 2014 Dec;77(6):541-6. doi: 10.1016/j.jpsychores.2014.08.005. Epub 2014 Aug 23.
BACKGROUND
The association of schizophrenia with peptic ulcer is not conclusive. In the last 30years, there has been little evaluation of peptic ulcer among schizophrenia patients.
METHODS
To explore the relation of peptic ulcer and schizophrenia during this new phase, we used the data from Taiwan insurance claims, identified 1496 schizophrenia patients (ICD-9-CM: 295) and selected 5984 non-schizophrenia controls that were frequency-matched by sex, age, and index year with schizophrenia patients during the years 1998-2001. All subjects were free of peptic ulcer at baseline. We measured incidences of peptic ulcer (ICD-9-CM: 531-534) until the end of 2009.
RESULTS
The incidence of peptic ulcer was 1.27 times higher in schizophrenia patients than in the control group (12.1vs. 9.52 per 1000 person-years). Patients are at higher risk taking anti-depression, anxiolytic and hypnotics or non-steroidal anti-inflammatory drugs. After controlling the confounding factors, schizophrenia patients had no significant increase incidence of peptic ulcer.
CONCLUSION
Schizophrenia patients have a slightly higher risk of peptic ulcer compared to the general population. This might be due to a higher rate of taking anti-depression, anxiolytic and hypnotics or non-steroidal anti-inflammatory drugs and alcoholism among this group.
背景
精神分裂症与消化性溃疡之间的关联尚无定论。在过去30年里，对精神分裂症患者中的消化性溃疡评估甚少。
方法
为了在这个新阶段探究消化性溃疡与精神分裂症之间的关系，我们使用了来自台湾保险理赔的数据，确定了1496例精神分裂症患者（国际疾病分类第九版临床修订本：295），并选择了5984例非精神分裂症对照，这些对照在性别、年龄和索引年份上与1998 - 2001年期间的精神分裂症患者进行了频率匹配。所有受试者在基线时均无消化性溃疡。我们测量了截至2009年底的消化性溃疡发病率（国际疾病分类第九版临床修订本：531 - 534）。
结果
精神分裂症患者的消化性溃疡发病率比对照组高1.27倍（每1000人年分别为12.1例和9.52例）。服用抗抑郁药、抗焦虑药、催眠药或非甾体抗炎药的患者风险更高。在控制混杂因素后,精神分裂症患者的消化性溃疡发病率没有显著增加。
结论
与普通人群相比，精神分裂症患者患消化性溃疡的风险略高。这可能是由于该组中服用抗抑郁药、抗焦虑药、催眠药或非甾体抗炎药以及酗酒的比例较高。
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