Saxena Smariti, Lakshminarayan Nagesh, Gudli Shanmukha, Kumar Manish
Senior Lecturer, Department of Public Health Dentistry, Institute of Dental Sciences , Bareilly, Uttar Pradesh, India .
Professor and Head, Department of Public Health Dentistry, Bapuji Dental College , Davangere, Karnataka, India .
J Clin Diagn Res. 2017 Feb;11(2):ZC47-ZC51. doi: 10.7860/JCDR/2017/23558.9355. Epub 2017 Feb 1.
From the oral health perspective, it is well established that microorganisms have an important role in caries aetiology. From the dawn of civilization, herbal plants have served an array of roles. a tradtional herbal Ayurvedic formula consists of three native fruits of india including () () (). As per Ayurvedic Formulary of India (AFI) is prepared by combining a 1:1:1 mixture of ground dry fruits called myrobalans. Till date, an inadequate number of clinical researches on herb based mouth rinses have been reported in Asia, especially in India and other Southeast Asian countries (where these products are most accepted and widely used). The present study was planned to assess the effectiveness of with its three constituents.
The objective of this study was to determine the effect of , , and aqueous extract rinses separately on count at various time intervals.
This is a double-blind, linear cross over, within group experimental trial conducted among subjects visiting the Department of Public Health Dentistry aged 15 to 40 years. In this design, subjects received all of the treatments sequentially in time. The independent variables to be assessed in this study were all the four interventions of herbal preparations used and the dependent variable assessed is anti bacterial efficacy. Each subject receives two or more different treatments. All the subjects were exposed to all four interventions: 1) ; 2) ; 3) ; and 4) and were provided 15 ml of the freshly prepared 10% rinse. The subjects were instructed not to eat or drink between salivary samples collection. Post rinse unstimulated salivary samples were collected at five minutes and 60 minutes intervals. All the salivary samples were transferred immediately to microbiological laboratory in sterile containers within one hour for microbiological analysis.
The mean Colony Forming Units (CFUs) of with when compared to other three intervention was significantly reduced at 5 minutes and 60 minutes (p=0.001). showed least reduction of mean CFUs when compared to other three groups.
It can be concluded that all four rinses were effective in reducing CFUs, but 10% has greater efficacy than its other constituents.
从口腔健康的角度来看，微生物在龋齿病因学中起着重要作用这一点已得到充分证实。自文明伊始，草药就发挥了一系列作用。一种传统的阿育吠陀草药配方由印度的三种本土水果组成，包括（）（）（）。根据《印度阿育吠陀配方》（AFI），它是通过将称为诃子的磨碎干果以1:1:1的比例混合制成的。迄今为止，在亚洲，尤其是在印度和其他东南亚国家（这些产品在这些国家最受欢迎且广泛使用），关于草药漱口水的临床研究数量不足。本研究旨在评估（该配方）及其三种成分的有效性。
本研究的目的是分别确定（该配方中三种成分的）水提取物漱口水在不同时间间隔对（口腔细菌）计数的影响。
这是一项在年龄为15至40岁的公共卫生牙科门诊患者中进行的双盲、线性交叉、组内实验性试验。在这个设计中，受试者依次接受所有治疗。本研究中要评估的自变量是所使用的草药制剂的所有四种干预措施，评估的因变量是抗菌效果。每个受试者接受两种或更多不同的治疗。所有受试者都接受了所有四种干预措施：1）（第一种草药成分）；2）（第二种草药成分）；3）（第三种草药成分）；4）（该配方整体），并提供15毫升新制备的10%漱口水。受试者被指示在采集唾液样本期间不要进食或饮水。漱口后，在5分钟和60分钟的间隔时间采集未刺激的唾液样本。所有唾液样本在一小时内立即转移到微生物实验室的无菌容器中进行微生物分析。
与其他三种干预措施相比，（该配方整体）在5分钟和60分钟时的平均菌落形成单位（CFUs）显著降低（p = 0.001）。与其他三组相比，（其中一种成分）的平均CFUs降低最少。
可以得出结论，所有四种漱口水在降低（口腔细菌）CFUs方面都是有效的，但10%的（该配方整体）比其其他成分具有更大的功效。
