Song Xingxing, Li Bingrong, Li Zongyao, Wang Jiantao, Zhang Dongfeng
Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
Department of Epidemiology and Health Statistics, the Medical College of Qingdao University, Qingdao, Shandong Province, People's Republic of China.
Nutr Res. 2017 Mar;39:14-24. doi: 10.1016/j.nutres.2017.01.004. Epub 2017 Jan 24.
Epidemiological studies evaluating the associations between serum copper and ratios of Cu/Zn and the preeclampsia (PE) risk in Asian population have produced inconsistent results. Therefore, we conducted a meta-analysis to summarize the relationships. We hypothesize that higher serum copper and ratios of Cu/Zn may increase the PE risk. A systematic literature search was performed in PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), VIP (Database of Chinese Scientific and Technical Periodicals) and Wangfang databases for relevant studies up to November 2016. Pooled standardized mean difference (SMD) was calculated with random effects model. The results showed that PE patients had a higher serum copper level [SMD (95% CI): 1.05 (0.34, 1.77), Z=2.88, P for Z=0.004; I=96.9%, P for I<0.0001] compared with healthy pregnancy controls. In subgroup analyses, a higher serum copper level in PE patients was observed in case-control studies [SMD (95% CI): 1.39 (0.44, 2.34)]. No significant difference was found between PE patients and healthy pregnancy controls for ratios of Cu/Zn [(SMD (95% CI): 0.26 (-0.77, 1.29), Z=0.49, P for Z=0.625; I=95.8%, P for I<0.0001)]. In conclusion, our meta-analysis indicates that a higher serum copper level is associated with an increased risk of PE. Further studies are needed to confirm these results in future research.
评估亚洲人群血清铜及铜/锌比值与先兆子痫（PE）风险之间关联的流行病学研究结果并不一致。因此，我们进行了一项荟萃分析以总结二者关系。我们假设较高的血清铜水平及铜/锌比值可能会增加PE风险。截至2016年11月，我们在PubMed、Web of Science、Embase、中国知网（CNKI）、维普（中文科技期刊数据库）和万方数据库中进行了系统的文献检索，以查找相关研究。采用随机效应模型计算合并标准化均数差（SMD）。结果显示，与健康妊娠对照组相比，PE患者的血清铜水平更高[SMD（95%CI）：1.05（0.34，1.77），Z = 2.88，Z的P值 = 0.004；I² = 96.9%，I²的P值<0.0001]。在亚组分析中，病例对照研究中观察到PE患者的血清铜水平较高[SMD（95%CI）：1.39（0.44，2.34）]。PE患者与健康妊娠对照组之间的铜/锌比值无显著差异[（SMD（95%CI）：0.26（-0.77，1.29），Z = 0.49，Z的P值 = 0.625；I² = 95.8%，I²的P值<0.0001]。总之，我们的荟萃分析表明，较高的血清铜水平与PE风险增加相关。未来研究需要进一步证实这些结果。
