Xin Lihong, Yang Xiao, Cai Guoqi, Fan Dazhi, Xia Qing, Liu Li, Hu Yanting, Ding Ning, Xu Shengqian, Wang Li, Li Xiaona, Zou Yanfeng, Pan Faming
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China.
Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China.
Biol Trace Elem Res. 2015 Nov;168(1):1-10. doi: 10.1007/s12011-015-0325-4. Epub 2015 Apr 15.
Many publications with conflicting results have evaluated serum levels of copper (Cu) and zinc (Zn) in patients with rheumatoid arthritis (RA). To derive a more precise estimation of the relationship, a meta-analysis was conducted. Relevant published data were retrieved through PubMed, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biomedical Database (CBM) before September 20, 2014. Weighted mean difference (WMD) with a 95 % confidence interval (95 % CI) was calculated using STATA 11.0. A total of 26 studies, including 1444 RA cases and 1241 healthy controls, were collected in this meta-analysis. Pooled analysis found that patients with RA had a higher serum level of Cu and a lower serum Zn level than the healthy controls (Cu (μg/dl), WMD = 31.824, 95 % CI = 20.334, 43.314; Zn (μg/dl), WMD = -12.683, 95 % CI = -19.783, -5.584). Subgroup analysis showed that ethnicity had influence on the serum level of Cu (μg/dl) (Caucasian, WMD = 43.907, 95 % CI = 35.090, 52.723, P < 0.001; Asian, WMD = 14.545, 95 % CI = -12.365, 41.455, P = 0.289) and Zn (μg/dl) (Caucasian, WMD = -11.038, 95 % CI = -23.420, 1.344, P = 0.081; Asian, WMD = -14.179, 95 % CI = -18.963, -9.394, P < 0.001) in RA and healthy controls. No evidence of publication bias was observed. This meta-analysis suggests that increased serum level of Cu and decreased serum level of Zn are generally present in RA patients.
许多结果相互矛盾的出版物评估了类风湿关节炎（RA）患者的血清铜（Cu）和锌（Zn）水平。为了更精确地估计两者之间的关系，进行了一项荟萃分析。在2014年9月20日前，通过PubMed、中国知网（CNKI）和中国生物医学数据库（CBM）检索相关已发表数据。使用STATA 11.0计算加权平均差（WMD）及95%置信区间（95%CI）。本荟萃分析共纳入26项研究，包括1444例RA患者和1241例健康对照。汇总分析发现，RA患者血清Cu水平高于健康对照，血清Zn水平低于健康对照（Cu（μg/dl），WMD = 31.824，95%CI = 20.334，43.314；Zn（μg/dl），WMD = -12.683，95%CI = -19.783，-5.584）。亚组分析显示，种族对RA患者和健康对照的血清Cu水平（μg/dl）（白种人，WMD = 43.907，95%CI = 35.090，52.723，P < 0.001；亚洲人，WMD = 14.545，95%CI = -12.365，41.455，P = 0.289）和血清Zn水平（μg/dl）（白种人，WMD = -11.038，95%CI = -23.420，1.344，P = 0.081；亚洲人，WMD = -14.179，95%CI = -18.963，-9.394，P < 0.001）有影响。未观察到发表偏倚的证据。该荟萃分析表明，RA患者普遍存在血清Cu水平升高和血清Zn水平降低的情况。
