Noel S B, Greer D L, Abadie S M, Zachary J A, Pankey G A
Department of Dermatology, Section on Infectious Diseases, Ochsner Clinic, New Orleans, LA 70121.
J Am Acad Dermatol. 1988 May;18(5 Pt 1):1023-30. doi: 10.1016/s0190-9622(88)70099-7.
Dematiaceous fungi have a diverse clinical spectrum that presents a difficult problem in diagnosis and treatment. These opportunistic pathogens are of concern in healthy, debilitated, or immunocompromised individuals. We describe three patients with localized cutaneous infections produced by dematiaceous filamentous fungal organisms with varying clinical presentations. Two patients were immunocompromised, and a third was otherwise healthy. The unusual clinical and unique histologic features of these difficult infections are reported in detail, as is their successful medical management with ketoconazole (Nizoral) and an experimental antifungal agent, fluconazole.
暗色真菌具有多样的临床谱，这在诊断和治疗方面带来了难题。这些机会致病菌在健康、虚弱或免疫功能低下的个体中令人担忧。我们描述了三例由暗色丝状真菌引起的局部皮肤感染患者，临床表现各异。两名患者免疫功能低下，第三名患者则身体健康。详细报告了这些难治性感染不寻常的临床和独特的组织学特征，以及使用酮康唑（里素劳）和一种实验性抗真菌药物氟康唑成功进行药物治疗的情况。
