Coldiron B M, Wiley E L, Rinaldi M G
Department of Dermatology, University of Cincinnati, OH.
J Am Acad Dermatol. 1990 Aug;23(2 Pt 2):363-7. doi: 10.1016/0190-9622(90)70223-5.
Annular, fungating, ulcerated lesions developed on both hands of a 64-year-old immunocompetent man 2 months after he was cut with barbed wire. A dematiaceous mold, Hormonema dematioides, heretofore not definitively associated with human disease, was grown from two separate tissue specimens during a period of 9 days. Histopathologic examination demonstrated rare small, periodic acid-Schiff-positive, hyaline, yeastlike organisms in tissue. Twelve weeks of empiric therapy with ketoconazole, 400 mg/day, was curative.
一名64岁免疫功能正常的男性双手在被铁丝网割伤2个月后出现环形、蕈样、溃疡性损害。从两份独立的组织标本中在9天内培养出一种此前未明确与人类疾病相关的暗色霉菌——皮炎外瓶霉。组织病理学检查显示组织中有罕见的小的、过碘酸希夫染色阳性、透明、酵母样生物体。给予酮康唑400mg/天进行12周的经验性治疗后治愈。
