Papalexopoulou Konstantina, Chalkias Athanasios, Pliatsika Paraskevi, Papalois Apostolos, Papapanagiotou Panagiotis, Papadopoulos Georgios, Arnaoutoglou Eleni, Petrou Anastasios, Gulati Anil, Xanthos Theodoros
National and Kapodistrian University of Athens, Medical School, Postgraduate Study Program (MSc) "Cardiopulmonary Resuscitation", Athens, Greece.
National and Kapodistrian University of Athens, Medical School, Postgraduate Study Program (MSc) "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece.
Heart Lung Circ. 2017 Aug;26(8):856-863. doi: 10.1016/j.hlc.2016.11.008. Epub 2016 Dec 19.
Centhaquin citrate is a novel agent being developed for use in the treatment of haemorrhagic shock. The aim of our study was to assess whether the administration of centhaquin would improve initial resuscitation success, 24-hour survival, and neurologic outcome compared with adrenaline alone in a porcine model of ventricular fibrillation.
Ventricular fibrillation was induced in 20 healthy Landrace/Large White piglets. The animals were randomised to receive placebo plus adrenaline 0.02mg/kg (n=10, Group C) and adrenaline 0.02mg/kg plus centhaquin 0.015mg/kg (n=10, Group S). All animals were resuscitated according to the 2010 European Resuscitation Council guidelines. Haemodynamic variables were measured before arrest, during arrest and resuscitation, and during the first two hours after return of spontaneous circulation (ROSC). Survival and a neurologic alertness score were measured at 24hours after ROSC.
A significant difference was observed in ROSC rate between the two groups, as 10 animals (100%) from Group S and 4 animals (40%) from Group C achieved ROSC (p=0.011). Systolic, diastolic, and mean aortic pressure and coronary perfusion pressure were significantly higher in Group S at the end of the second cycle of CPR. In our study, all subjects with ROSC survived for 24hours, while we observed no statistically significant differences in neurologic examination (Group C 100±0, Group S 96±12.64; p=0.527).
The addition of centhaquin to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.
柠檬酸辛喹铵是一种正在研发用于治疗失血性休克的新型药物。我们研究的目的是评估在猪心室颤动模型中，与单独使用肾上腺素相比，给予辛喹铵是否能提高初始复苏成功率、24小时生存率及神经功能结局。
对20只健康的长白/大白仔猪诱发心室颤动。将动物随机分为接受安慰剂加0.02mg/kg肾上腺素组（n = 10，C组）和0.02mg/kg肾上腺素加0.015mg/kg辛喹铵组（n = 10，S组）。所有动物均按照2010年欧洲复苏委员会指南进行复苏。在心脏骤停前、心脏骤停及复苏期间以及自主循环恢复（ROSC）后的前两小时测量血流动力学变量。在ROSC后24小时测量生存率及神经清醒评分。
两组间ROSC率存在显著差异，S组10只动物（100%）实现ROSC，C组4只动物（40%）实现ROSC（p = 0.011）。在心肺复苏第二个周期结束时，S组的收缩压、舒张压、平均主动脉压及冠状动脉灌注压显著更高。在我们的研究中，所有实现ROSC的受试者均存活24小时，而我们在神经功能检查中未观察到统计学显著差异（C组100±0，S组96±12.64；p = 0.527）。
在肾上腺素中添加辛喹铵可提高猪室颤性心脏骤停模型的ROSC率。
